NYU BioWave & NYU BioSim: Automating Analysis of BioChemical Pathways
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چکیده
This paper describes a set of novel tools for analyzing trajectories of bio-chemical pathways, where these trajectories are obtained either through in silico simulations or through in vitro or in vivo time-course data. In particular, we describe two interesting tools—NYU BioSim and NYU BioWave, within a more general Simpathica system—that store, analyze and group time-series representations of bio-chemical trajectories by using a multiresolution time-frequency analysis for optimal basis selection. We illustrate, by examples, how it can be used to understand the behavior of a family of artificial biological circuits. We also show how these tools interact with a model-checking system to present qualitative distinctions among the groups within the family of biological circuits or among the different multi-modal behaviors of
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تاریخ انتشار 2004